A Computer Scientist's Guide to Cell Biology: A travelogue by William W. Cohen

By William W. Cohen

This functional advisor presents a succinct remedy of the final suggestions of cellphone biology, furnishing the pc scientist with the instruments essential to learn and comprehend present literature within the field.

The e-book explores 3 various aspects of biology: biological structures, experimental methods, and language and nomenclature. After a quick creation to telephone biology, the textual content specializes in the foundations in the back of the most-widely used experimental strategies and mechanisms, pertaining to them to well-understood ideas in computing device technology.

The presentation of the cloth has been ready for the reader’s speedy seize of the subject: reviews on nomenclature and heritage notes might be ascertained at a look, and crucial vocabulary is boldfaced in the course of the textual content for simple identification.

Computer technology researchers, execs and machine technological know-how scholars will locate this an incomparable source and a very good start line for a extra accomplished exam of mobile biology.

"This concise publication is a wonderful advent for desktop scientists to the intriguing revolution lower than means in molecular biology. It presents lucid, high-level descriptions of the basic molecular mechanisms of lifestyles, and discusses the computational ideas concerned. I want this little gem used to be to be had whilst i used to be ‘learning the ropes’– it can were my first selection of examining material."

--Roni Rosenfeld, Carnegie Mellon University

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Containing proteins, is SDS-PAGE, which is short for sodium dodecyl sulfate (SDS) polyacrylamide-gel electrophoresis. SDS is a detergent, which is mixed with the protein solution before adding it to the gel: it acts to unfold the proteins from their natural shapes into simple linear chains. The unfolded proteins migrate through the gel at a rate determined only by their sizes (not their shape after folding). A typical application of SDS-PAGE uses a single gel to compare several mixtures, each of which is placed in a different lane of the gel.

Every location on the paper to which X sticks corresponds to a protein in M with which X interacts. This technique is called a Western blot. Performing the analogous operations starting with a (one-dimensional) gel containing RNA molecules in order to determine which RNAs hybridize to some DNA molecule X is called a Northern blot. Performing a Northern blot with DNA instead of RNA is called a Southern blot. ) The grandchild of the Northern blot is the infamous gene chip (and/or the closely related microarray), which I will talk about next.

Figure 24. Fluorescent microscope images. 42 A Computer Scientist’s Guide to Cell Biology One important type of microscope for use with fluorescent dyes is the confocal microscope, in which aggressive filtering is used, so that not only is reflected light filtered out, but also only light emitted by a very small part of the image is detected. A confocal microscope thus needs to scan progressively through a specimen. Good confocal microscopes can produce 3D images that include information from many different dyes.

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