Affinity Capillary Electrophoresis in Pharmaceutics and by Reinhard Neubert (Editor), Hans-Hermann Ruttinger (Editor)

By Reinhard Neubert (Editor), Hans-Hermann Ruttinger (Editor)

This quantity provides breakthroughs and strategies in affinity capillary electrophoresis to degree and make certain the physicochemical and thermodynamic parameters of drug compounds. It discusses ideas to discover and represent interactions to facilitate advancements in managed drug supply and focusing on.

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For instance, for the determination of the content of active pharmaceutical ingredients in tablets, creams, and injectables, the MEKC mode often offers advantages over the CZE mode. Principles of Capillary Electrophoresis D. 17 Capillary Electrochromatography Capillary electrochromatography is very similar to MEKC. It is a technique where the flow of the mobile phase through a column packed with an HPLC stationary phase is effected by the application of an external voltage. In contrast to high-pressure pumping, no back-pressure arises, allowing the use of smaller particle sizes than in HPLC.

Organic solvents such as methanol, iso-propanol, and acetonitrile have been used in practical work. Micellar electrokinetic chromatography is applied for the analysis of a wide variety of organic substances, ionic and nonionic in nature. For instance, for the determination of the content of active pharmaceutical ingredients in tablets, creams, and injectables, the MEKC mode often offers advantages over the CZE mode. Principles of Capillary Electrophoresis D. 17 Capillary Electrochromatography Capillary electrochromatography is very similar to MEKC.

T. Hansen. J. Pharm. Biomed. Anal. 15 (1997), 1077. T. Okada. J. Chromatogr. A 771 (1997), 275. 2 Theory of Affinity Electrophoresis Hans-Hermann Ru¨ttinger Martin-Luther-University Halle-Wittenberg, Halle, Germany I. INTRODUCTION More or less specific noncovalent molecular interactions are ubiquitous in biological systems. Signal transduction such as hormone–receptor binding, transcription of hereditary information, enzyme substrate binding, and regulation of enzyme activity are only few examples.

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