Animal Models of Epilepsy: Methods and Innovations by Cody J. Locke, Kim A. Caldwell, Guy A. Caldwell (auth.),

By Cody J. Locke, Kim A. Caldwell, Guy A. Caldwell (auth.), Scott C. Baraban (eds.)

With its complicated anatomical, molecular, electrophysiological and behavioral parts, epilepsy presents the neuroscientist with approximately boundless possibilities to check easy neurobiological mechanisms. In Animal versions of Epilepsy: equipment and Innovations, in demand investigators within the box research a number of novel types of epilepsy in mice in addition to in genetically tractable "simple" species equivalent to Drosophila melanogaster (fruit flies), Caenorhabditis elegans (worms), Xenopus laevis (tadpoles) and Danio rerio (zebrafish). whereas overlaying a few conventional versions, the amount additionally explores the latest thoughts like modeling seizure job in silica and complicated recommendations for seizure detection and gene treatment. As a quantity within the profitable Neuromethods™ sequence, the chapters offer transparent, step by step protocols and thought-provoking experiences of the newest developments within the field.

Comprehensive and state-of-the-art, Animal types of Epilepsy: equipment and Innovations is a perfect advisor for scientists who desire to extend our knowing of the pathogenesis of this neurological disorder.

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68. Dupuy D, Bertin N, Hidalgo CA, Venkatesan K, Tu D, Lee D, Rosenberg J, Svrzikapa N, Blanc A, Carnec A, Carvunis AR, Pulak R, Shingles J, Reece-Hoyes J, Hunt-Newbury R, Viveiros R, Mohler WA, Tasan M, Roth FP, Le Peuch C, Hope IA, Johnsen R, Moerman DG, Barabasi AL, Baillie D, Vidal M. Genome-scale analysis of in vivo spatiotemporal promoter activity in Caenorhabditis elegans. Nat Biotechnol 2007;25(6): 663–8. 69. Kim SK, Lund J, Kiraly M, Duke K, Jiang M, Stuart JM, Eizinger A, Wylie BN, Davidson GS.

15. Royden CS, Pirrotta V, Jan LY. The tko locus, site of a behavioral mutation in D. melanogaster, codes for a protein homologous to prokaryotic ribosomal protein S12. Cell 1987;51:165–173. 16. Glasscock E, Tanouye MA. Drosophila couch potato mutants exhibit complex neurological abnormalities including epilepsy phenotypes. Genetics 2005;169: 2137–2149. 17. Hekmat-Scafe DS, Lundy MY, Ranga R, Tanouye MA. Mutations in the K+/Clcotransporter gene kazachoc (kcc) increase 18. 19. 20. 21. 22. 23. 24.

Fukata Y, Adesnik H, Iwanaga T, Bredt DS, Nicoll RA, Fukata M. Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission. Science 2006;313(5794):1792–5. Jones DL and Baraban SC. Characterization of inhibitory circuits in the malformed hippocampus of Lis1 mutant mice. J Neurophysiol 2007;98(5):2737–46. Locke CJ, Williams SN, Schwarz EM, Caldwell GA, Caldwell KA. Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C.

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