By David B. Rosenfield M.D. (auth.), Santosh A. Helekar (eds.)
Basic learn over the past decade or has exposed similarities among speech, particularly its sensori-motor elements, and vocal verbal exchange in different non-human species. the main complete reports thus far were performed in songbirds. Songbirds supply us a version process to review the interactions among developmental or genetic predispositions and tutor-dependent affects, at the studying of vocal verbal exchange. Songbird examine has elucidated mobile and molecular mechanisms underlying studying and construction of vocal styles, conception of vocal sounds, vocal motor keep watch over and vocal neuromotor plasticity. extra lately, the total genome of the songbird zebra finch has been sequenced. those discoveries, besides the id of numerous genes implicated in familial human speech and language issues, have made it attainable to appear for analogues of speech and language disorder in zebra finches, at the very least on the perceptual and sensori-motor degrees. techniques particularly have led us toward the improvement of animal types of human speech stipulations, specifically developmental stuttering and a familial verbal dyspraxia linked to a mutation within the gene for the transcription issue FoxP2. paintings on different animals that exhibit developmental sensori-motor studying of vocal sounds used for communique have additionally proven major development, resulting in the potential for improvement of types of speech and language disorder in them. between mammals, the important ones comprise dolphins and whales. In non-human primates, whereas vocal studying in step with se isn't popular, investigations on their communicative skills have thrown a few gentle at the rudiments of language. those concerns make the ebook of a publication thinking about animal types of speech and language issues, detailing the general investigative strategy of neurobehavioral experiences in animals able to vocal verbal exchange and discovered vocalizations, a much-needed and precious undertaking. it'll function a unifying evaluation of analysis during this new multidisciplinary frontier, spanning the molecular to the behavioral, for clinicians and researchers, in addition to a educating source for complex speech pathology and neuroscience scholars. This e-book may also be the 1st of its kind.
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Extra info for Animal Models of Speech and Language Disorders
In addition to the contributions of FOXP2 to human language development, FOXP proteins have been shown to play functional roles in diverse processes ranging from organ development to tumorigenesis . Both FOXP1 and FOXP2 have been implicated in cancer progression [53, 54]. Furthermore, studies of mouse models in which these genes are ‘knocked out’ have implicated Foxp1/2 in lung development and Foxp1/4 in heart development. Foxp1 has shown to be crucial for determining motor neuron identity in the spinal cord [55, 56].
FOXP1 mutations were also found in an independent screen of patients with moderate ID, general developmental delay, reduced expressive and receptive vocabulary and general speech delay . In a large genome-wide screen for CNVs in 1,523 patients, three cases were identified with deletions that only affected the FOXP1 locus. However, it should be noted that a single deletion affecting four genes (FOXP1, EIF3E3, PROK2 and GPR27) similar to that observed by Pariani et al. was also found when screening a panel of 4,104 control DNA samples.
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