Antiepileptic Drugs: Pharmacology and Therapeutics by F. E. Dreifuss, N. B. Fountain (auth.), Professor Mervyn J.

By F. E. Dreifuss, N. B. Fountain (auth.), Professor Mervyn J. Eadie AO, MD, PhD, Dr. Frank J. E. Vajda M.D. (eds.)

In 1985, quantity seventy four of the Springer-Verlag instruction manual of Experimental Phar­ macology, less than the editorship of H. -H. Frey and D. Janz, seemed. during this quantity the then to be had info regarding antiepileptic medicinal drugs have been col­ lated and analysed. Over the intervening years wisdom during this quarter has grown gradually. extra new antiepileptic medicines than the entire variety of brokers that have been in universal use 15 years in the past have within the period both come directly to the marketplace or are approximately to take action. to boot, extra brokers are at a pretty complex degree of improvement, when the already verified medications have often held their locations in scientific perform. wisdom of epileptogenesis has complex significantly. The mechanisms of motion of antiepileptic medicinal drugs on the molecular point and in quite a few animal versions of epileptic seizures and of the epileptic country are far better understood than they have been formerly. besides, additional info is out there about the average heritage of human epilepsy, and this data is necessary in making optimum use of some of the brokers which are now on hand. consequently, it has appeared applicable at this level within the evolution of information to provide a moment quantity facing Antiepileptic medications within the guide of Experimental Pharmacology series.

Show description

Read or Download Antiepileptic Drugs: Pharmacology and Therapeutics PDF

Best pharmacology books

Additional info for Antiepileptic Drugs: Pharmacology and Therapeutics

Sample text

With autonomic symptoms 4. With psychic symptoms B. Complex partial seizures (with impairment of consciousness) 1. Beginning as simple partial seizures and progressing to impairment of consciousness a) With no other features b) With features as in A. 1-4 c) With automatisms 2. With impairment of consciousness at the onset a) With no other features b) With features as in A. 1-4 c) With automatisms C. Partial seizures secondarily generalized II. Generalized seizures (convulsive or non convulsive ) Generalized seizures are those in which the first clinical changes indicate initial involvement of both hemispheres.

E. Interactions ............................................... F. Adverse Effects ........................................... I. Dose-Related Adverse Effects ......................... II. Idiosyncratic Adverse Effects .......................... G. Use of Felbamate in Practice ................................ I. Role of Felbamate Blood Levels ....................... II. Managing Drug Interactions ........................... III. Stopping Felbamate ..................................

IV. Drug Interactions .................................... V. Antiepileptic Efficacy and Adverse Effects .............. Remacemide ............................................. I. Chemistry .......................................... II. Pharmacodynamics ................................... 1. Anticonvulsant Activity in Animal Models ............ 2. Mechanism of Action .............................. 3. Other Pharmacological Effects and Toxicology Data . . III. Pharmacokinetics ....................................

Download PDF sample

Rated 4.09 of 5 – based on 9 votes