Aquaporins by Jennifer M. Carbrey, Peter Agre (auth.), Prof. Dr. Eric

By Jennifer M. Carbrey, Peter Agre (auth.), Prof. Dr. Eric Beitz (eds.)

The aquaporin box has matured at an incredibly quick velocity and we're on the verge to enhance critical ideas to therapeutically modulate aquaporin functionality without delay or through regulatory networks. Key necessities can be found this day: i. a substantial (and growing to be) variety of aquaporin crystal constructions for the rational layout of inhibitory molecules, ii. problematic molecular dynamics simulation innovations for theoretical analyses of selectivity mechanisms and docking experiments, iii. finished information on aquaporin immunohistochemistry, iv. aquaporin knockout animals for physiological experiences, and v. assay structures for compound library screenings. The constitution of this quantity on aquaporins follows the issues laid out above and therefore covers the advancements from easy examine to power pharmacological use. positioned among pharmacology textbooks and up to date clinical papers this ebook presents a well timed assessment for readers from the basic in addition to the utilized disciplines.

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Agre parasitophorous vacuolar membrane that surrounds all of the parasites, and the parasite plasma membrane. When the gene encoding the aquaglyceroporin in Plasmodium berghei, a mouse malaria parasite, was disrupted the parasites grew more slowly in mice, which allowed the mice to survive longer (Promeneur et al. 2007). AQP9 null mice infected with Plasmodium berghei survived longer during the initial phase of the infection compared with wild-type mice (Liu et al. 2007). Glycerol seems to be important for maximal Plasmodium growth and virulence.

3 Surface Structure of AQPs Involved in Membrane Junctions . . . . . . . . . 4 Unsolved Riddles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 AQP Trafficking . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 AQP Gating . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Anion Transport . . . . . . . . . . . . . . . .

1 The AQP Fold . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 The Structure of the Pore . . . . . . . . . . . . . . . . . . . . . . . . 3 Surface Structure of AQPs Involved in Membrane Junctions . . . . . . . . . 4 Unsolved Riddles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 AQP Trafficking . . . . . . . . . . .

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