By Linda A. Felton, James W. McGinity
This hugely praised booklet provides an in-depth research of actual and chemical homes and functions of aqueous-based polymeric coatings-covering covered dosage kinds, movie defects, and polymer characterization. New chapters on plastisizers and their functions in pharmaceutical coatings, adhesion of polymeric motion pictures to sturdy substrates, and the impression of pigments on houses of the polymeric coating structures are integrated during this 3rd variation. also, this identify presents new fabric on polymer interactions with medications and excipients and actual getting older of polymeric movies.
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Extra info for Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, 3rd Edition (Drugs and the Pharmaceutical Sciences)
24% DBS 8% Coat. 24% DBS 60 Cumulative % 40 20 0 1 2 3 4 Time (hrs) 5 Figure 21 Effect of film coat level on dissolution. 6 Pseudolatex Dispersions for Controlled Drug Delivery 25 Cumulative % Released 100 80 60 40 6% Coat. 16% DBS 6% Coat. 18% DBS 6% Coat. 20% DBS 6% Coat. 22% DBS 6% Coat. 24% DBS 20 1 2 3 4 Time (hrs) 5 6 Figure 22 Effect of plasticizer level on dissolution. beads were sealed and the coating system stabilized; then the rate was increased to up to 10 mL/min. The time, temperature, and humidity parameters were not optimized in this comparative study, so the degree of coalescence may have varied.
Aten WC, Wassenburg TC. Influence of the surfactant distribution on the water resistance of clear latex films. Plastics Rubber Process Appl 1983; 3(2):99–104. Ghebre-Sellassie I, Nesbitt RU, Wang J. In: McGinity JW, ed. Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms. 2nd ed. New York: Marcel & Dekker, 1997. Mehta AM. In: McGinity JW, ed. Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms. 2nd ed. New York: Marcel & Dekker, 1997. Li J-X, Carlin BA, Lee JT, et al. Effect of high-humidity coating process on the drug release from pellets coated with ethylcellulose aqueous dispersion NF.
This work thus differentiated between coalescence, which was defined as the break-up of the hydrophilic layer, and subsequent polymer chain interdiffusion. Nicholson and Wasson (15) divided coalescence mechanisms into two groups: (i) those dependent on sintering or capillarity processes, which dominate when there are polar repulsions present; and (ii) those dependent on polymer chain interdiffusion, when there is very little repulsion between particles. According to Voyutskii (16), interdiffusion of polymer chains (autohesion) across what was the interface between discrete polymer spheres is the final step in the formation of integral homogeneous latex films.