Toxicological profiles - 1,1-dichloroethane by Agency for Toxic Substances and Disease Registry, 2

By Agency for Toxic Substances and Disease Registry, 2

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Furthermore, the doses given to mice by gavage were approximately six times higher than the drinking water concentrations. Species differences in susceptibility may also have played a role, as rats used in the NCI study showed adverse effects at a dose that was without effect in the Klaunig et al. (1986) study. , the finding of 475 mg/kg/day as a LOAEL in the NCI study and the same dose as a NOAEL in the Klaunig study. 3 Dermal Exposure No studies were located regarding the following health effects in humans or animals after dermal exposure to 1,1-dichloroethane.

In addition in vitro and in vivo assays have been conducted using rat and mouse organs (Colacci et al. 1985). Results of these studies are summarized in Table 2-5. Results from three studies conducted in S. typhimurium tester strains were conflicting. 1,1-Dichloroethane was nonmutagenic in yeast cells even in the presence of metabolic activation system. However, because of insufficient reporting of data by Bronzetti et al. (1987) and Simmon et al. (1977), no assessment of the genotoxic potential of 1,1-dichloroethane in S.

E. 2 Oral Exposure No studies were located regarding the distribution of 1,1-dichloroethane following oral exposure in humans or animals. 3 Dermal Exposure No studies were located regarding the distribution of 1,1-dichloroethane following dermal exposure in humans or animals. 2 mg [ C]-1,1-dichloroethane/kg and sacrificed 22 hours later. 1,1-Dichloroethane was covalently bound to proteins, RNA, and DNA of liver, kidney, lung, and stomach. The extent of binding was greatest in the tissue proteins and least in the DNA.

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